Internet star “Grumpy Cat” has died at the age of seven, her owners said early Friday.

“We are unimaginably heartbroken to announce the loss of our beloved Grumpy Cat,” they said in a statement on Twitter.

The famous feline, whose frowning visage endeared her to millions of fans across social media and saw her photographed with celebrities including Stan Lee and Jennifer Lopez, passed away Tuesday “in the arms of her mommy, Tabatha” at her home in Arizona.

“Despite care from top professionals, as well as from her very loving family, Grumpy encountered complications from a recent urinary tract infection that unfortunately became too tough for her to overcome,” they said.

“Besides being our baby and a cherished member of the family, Grumpy Cat has helped millions of people smile all around the world — even when times were tough.