Iranian and American forces were racing each other early Saturday to recover a crew member of the first US fighter jet to go down inside Iran since the start of the war.
Tehran said it had shot down the F-15 warplane, while US media reported American special forces had rescued one of its two crew members, with the other still missing.
Iran's military also said it downed a US A-10 ground attack aircraft in the Gulf, with US media saying the pilot was rescued.
The war erupted more than a month ago with US-Israeli strikes on Iran that killed supreme leader Ali Khamenei, triggering retaliation that spread the conflict throughout the Middle East, convulsing the global economy and impacting millions of people worldwide.
US Central Command did not immediately respond to a request for comment on the loss of the F-15, but White House Press Secretary Karoline Leavitt said: "The president has been briefed".
President Donald Trump told NBC the F-15 loss would not affect negotiations with Iran, saying: "No, not at all. No, it's war."
- 'Valuable reward' -
A spokesperson for the Iranian military's central operational command said "an American hostile fighter jet in central Iranian airspace was struck and destroyed by the IRGC Aerospace Force's advanced air defence system".
"The jet was completely obliterated, and further searches are ongoing."
An Iranian television reporter on a local official channel said anyone who captured a crew member alive would "receive a valuable reward".
The US military has announced the loss of several aircraft during Iran operations, including one tanker that crashed in Iraq and three F-15s shot down by Kuwaiti friendly fire.
Retired US brigadier general Houston Cantwell -- who has 400 hours of combat flight experience -- said key goals for downed pilots include determining their location and figuring out how to communicate.
"My priority would be, first of all, concealment, because I don't want to be captured," he told AFP.
- Blown-out windows -
Fresh strikes meanwhile hit Israel, Iran, Lebanon and Gulf countries -- and large blasts rocked northern Tehran, an AFP journalist said. Israel said it had launched a wave of strikes in the Iranian capital, alongside parallel attacks in Beirut.
Strikes by all sides have increasingly targeted economic and industrial sites, raising fears of wider disruption to global energy supplies.
In the area around a bridge west of Tehran that was targeted by the United States, an AFP reporter saw a villa and residential buildings with blown-out windows -- but no military installations.
According to the martyrs foundation of Alborz province, cited by the official IRNA agency, the attack killed 13 civilians and wounded dozens.
- Ex-FM urges deal -
Writing in the US journal Foreign Affairs, Iran's former foreign minister, Mohammad Javad Zarif, said Tehran should make a deal with Washington to end the war by offering to curb its nuclear programme and reopen the Strait of Hormuz in exchange for sanctions relief.
Iran has virtually blocked the key waterway since the war began, where one-fifth of the world's oil and natural gas normally passes.
Of the few ships that have managed to cross, most have had links to Iran, with 60 percent of commodity-bearing ships crossing the strait either coming from Iran or heading there, an AFP analysis of maritime data showed.
Iranian military spokesperson Ebrahim Zolfaghari warned that Iran would increase its own attacks on energy sites in the region in response to threats from Trump of attacks on infrastructure.
A drone attack on a refinery owned by Kuwait's national oil company on Friday sparked fires, while a separate Iranian attack damaged a power and desalination complex.
Bahrain said four of its citizens sustained "minor injuries" as a result of shrapnel from an intercepted Iranian drone.
And one person was killed and four others injured after a fire at a gas complex in the United Arab Emirates caused by falling debris from an intercepted attack.
- Bridge destroyed in Lebanon -
The Israeli military said Friday it had struck more than 3,500 targets across Lebanon in the month since fighting with Iran-backed Hezbollah began.
It added that it would attack two bridges in Lebanon's eastern Bekaa region "in order to prevent the transfer of reinforcements and military equipment".
Lebanese state media later reported that Israel destroyed one bridge in the region.
Lebanon's health ministry said Thursday that 1,345 people had been killed -- and 4,040 wounded -- since the start of the war.
Hezbollah has so far not announced its losses.
